Mohamed Bayo was born on 4 June 1998 in Clermont-Ferrand, France, and represents Guinea at international level. He came through the Clermont Foot academy and, after a loan spell at Dunkerque, finished as Ligue 2's top scorer in 2020–21 with 22 goals, helping Clermont win promotion to Ligue 1. That season he was also named in the UNFP Ligue 2 Team of the Year.

In July 2022 he joined Lille, and later had loan spells at Le Havre, Antwerp and Gaziantep. A Guinea international, he was part of their squads at the 2021 and 2023 Africa Cup of Nations. He signed a four-year contract with Samsunspor on 4 September 2026.